This study seeks to assess the response of osteoarthritis of the knee to different dosing and injection protocols of adipose-derived (liposuction) mesenchymal stem cells collected from the participant (autologous). 40 participants will be enrolled in the Melbourne study and randomly separated into either one of three treatment groups or a control group receiving conservative management. If the treatment groups show significant and conclusive improvements the control group will be offered cross over at 12months. This study is funded and there will be no treatment charge to the participants.