Brain tumours

Stem cells have been used to assist patients with cancer for many years. Listed below is a trial investigating the use of stem cells to assist in recovery from childhood brain tumours. Click on the link provided to find out more about the trial. It remains too early to know if the approach will be suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Brain tumours

  • Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours Location: Australia
    Overview: This trial aims to assess the safety and effectiveness of using blood stem cells that have been genetically modified to treat children with brain tumours. The clinical trial is being conducted by the Kids Cancer Project in Alexandria New South Wales in conjunction with the Australian Department of Innovation, Industry Science and Research. The trial hopes to recruit 15 children with either high grade primary Glioma or lower grade recurrent brain tumours such as Glioma, Ependymoma, Medulloblastoma or teratogenic tumours among others. Stem cells will be harvested from the participant's blood after they have received an injection of granulocyte colony stimulating factor (G-CSF) to release the stem cells from their bone marrow. The stem cells will be genetically modified in the laboratory to make them more resistant to chemotherapy drugs. The trial participants will receive an intravenous (IV) infusion of these expanded, modified stem cells, and then 21 days later be treated with standard chemotherapy for such tumours. Participants will be monitored for complications and the effectiveness will be assessed by conducting MRI scans of the brain. The trial commenced in July 2012.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells