Leukaemia

Stem cells have been used to treat patients with leukaemia for many years. Listed below are some trials investigating new use of stem cells to assist patient recovery. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Leukaemia

  • Human Placental-Derived Stem Cell Transplantation Location: US
    Overview: This trial aims to compare the safety of transplanting combinations of stem cells from placental with cord blood for a number of different malignant and benign haematological disorders. The trial is being conducted by the New York Medical College and will investigate whether giving placental stem cells at the same time as umbilical cord blood effects the survival of the transplanted stem. The trial expects to enrol 30 patients between March 2013 and December 2019 with any one of 16 diseases including several kinds of Leukaemia, Aplastic Anaemia as well as several benign but severely debilitating, incurable enzyme-linked metabolic disorders such as Gaucher's & Nieman-Pick disease. Patients will be monitored for complications and therapeutic benefit for nine months after the injection.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Placental Stem Cells
  • Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia Location: Australia
    Overview: This trial aims to evaluate stem cell transfusions from partially mismatched donors for patients with acute myeloid leukaemia (AML).The clinical trial is being conducted at St Vincent's Hospital in Sydney and proposes to enrol 12 patients with AML between November 2012 and January 2015. Participants will receive a nine-day induction chemotherapy treatment for AML. Concurrently the donor receives five days of G-CSF injections, starting on day four. On day 9, the stem cells will be harvested from the donor's peripheral blood via apheresis. The stem cells are divided into four aliquots, the first of which is injected into the patient on the same day. A bone marrow biopsy will be performed between four to five weeks after the stem cell infusion and if remission is confirmed, the patient will be commenced consolidation chemotherapy. If remission is not confirmed, the patient will receive another nine days of induction chemotherapy followed by an aliquot of stem cells and have a further bone marrow biopsy after four weeks. If the patient is seen to be in remission two further cycles of consolidation chemotherapy are given each followed by an aliquot of stem cells. Participants will be monitored for complications and assessed for changes in their clinical condition, including monitoring for evidence of graft versus host disease.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Haploidentical Donor Stem Cell Transplantation for Haematological Malignancies Location: Australia
    Overview: This trial aims to investigate the use of blood stem cells from related donors for the treatment of haematological malignancies such as leukaemia and lymphoma. The trial is being conducted at St Vincent's Hospital in Sydney plans to recruit five patients between May 2009 and February 2014. Participants will receive stem cells from a related donor (haploidentical identical) blood stem cells. Donors will be injected with GCSF following which they will have stem cells harvested from their bone marrow as well as from their peripheral blood (GCSF primed bone marrow harvest + augmentation with peripheral blood stem cells). Patients will initially undergo chemotherapy following which they will be injected with donated stem cells. The patients will also be given the standard GVHD prevention immunosuppression regime. Participants will be monitored for complications and assessed for changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells