Periodontitis

Stem cells from dental pulp and fat are being investigated as possible treatments for gum inflammation. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Periodontitis

  • An Exploratory Open Trial to Examine the Safety of Transplantation of Autologous Adipose Tissue-derived Stem Cells for Periodontal Regeneration Location: Japan
    Overview: This trial aims to investigate the safety and effectiveness of the patient's own fat mesenchymal stem cells in treating periodontal disease. The trial is being conducted by the Osaka University School of Dentistry and expects to enrol 15 subjects. The subjects will have stem cells harvested from their fat using liposuction and these will be transplanted into a selected tooth socket. Participants will be monitored for complications and assessed for increased bone growth and tooth stability. The trial commenced in November 2012 and is currently recruiting subjects.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Pulp Regeneration after Pulpectomy by Transplantation of Autologous Pulp Stem Cells Location: Japan
    Overview: This trial is investigating the use of stem cells from the patient's dental pulp in treating pulpitis. The trial is being conducted at the Center of Advanced Medicine for Dental and Oral Diseases at the National Center for Geriatrics and Gerontology in Aichi and proposes to recruit five patients between March 2013 and February 2017. In the study stem cells will be obtained from wisdom teeth or other supernumerary or less precious teeth and then transplanted to the bed of a tooth that has been treated for intractable or incurable pulpitis. G-CSF will also be injected into the bed at the time of transplant to stimulate engraftment. Participants will be monitored for complications following the procedure, and changes in clinical condition.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Adult Dental Pulp Stem Cells