Crohn's Disease

Stem cells from bone marrow are being investigated as possible treatments for Crohns Disease. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Crohn's Disease

  • Mesenchymal Stem Cell Therapy for the Treatment of Severe or Refractory Inflammatory and/or Autoimmune Disorders Location: Belgium
    Overview: This trial is investigating the effect of donated bone marrow stem cells in people suffering from Crohn's disease. Mesenchymal stem cells were collected from the bone marrow of healthy volunteers and expanded in the laboratory before being administered in the trial. The trial is being conducted in in Liege, Belgium in patients who have not responded to conventional treatment. There is no control group in this trial and participants will be accessed for changes in blood cell profile and markers of the immune system. The trial is expected to run until June 2016 and enrol 20 participants.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Crohn's Allogeneic Transplant Study Location: US
    Overview: This trial is investigating the possible therapeutic effect of transplanting donated bone marrow cells into patients with severe Crohn's Disease, an autoimmune inflammatory bowel disease. The study is being conducted by the Fred Hutchinson Cancer Research Centre at the University of Washington, in Seattle. All participants will have severe Crohn’s Disease that has not responded to other treatments. They will initially be treated with low dose radiation and chemotherapy (to suppress the immune system), then transplanted with bone marrow from a matched, healthy donors. The patient will continue to get immunosuppressive therapy (tacrolimus) for three months following the bone marrow transplant. Participants will be monitored regularly over the next five years. The trial aims to enrol 12 patients by April 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • A Phase I Study Evaluating Autologous Bone Marrow Derived Mesenchymal Stromal for Crohn's Disease. (EPIC/MSC/IBD) Location: US
    Overview: This trial aims to evaluate the safety and tolerability of the patient's mesenchymal stromal cells (MSCs) in the treatment of young adults with moderate to severe Crohn's Disease. The trial is being conducted at Emory University in Atlanta in conjunction with the Atlanta Clinical and Translational Science Institute. Participants in the trial will receive an intravenous (IV) infusion of MSCs obtained from their own bone marrow. The cells will be expanded in the laboratory before infusion and participants will randomly divided into different groups. Each group will receive a different dose of cells. Participants will be monitored for complications and changes in their clinical condition. The trial seeks to enrol 16 participants between July 2012 and July 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • A Single Centre Phase II Study Of Haematopoietic Stem Cell Transplantation for Severe Auto-Immune Diseases Location: Australia
    Overview: This trial is evaluating the use of combining immunosuppression and the patient's bone marrow stem cells in patients with serious diseases of the immune system which have not responded to conventional treatments. The trial is being conducted at St Vincent's Hospital in Sydney and began recruiting patients in March 2011 with plans to recruit 30 subjects by December 2015. The conditions being investigated in the trial include Scleroderma, Multiple Sclerosis, Systemic Lupus Erythematosus (SLE), vasculitis, Crohn's disease and Behcet's disease. Participants will be given Granulocyte Colony Stimulating Factor (G-CSF) to stimulate the bone marrow into releasing stem cells, which will then be harvested from the blood of each participant. The patients will then undergo a course of intensive chemotherapy and/or immunotherapy depending on the individual condition after which they will receive an infusion of their own stem cells. Participants will be monitored for complications and assessed for changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells