EUCTR2010-019774-33-ES

This trial is investigating the effects of patient's own stem cells as therapy for critical ischemia in lower limbs in patients with type 2 diabetics. The trial is being conducted by the Fundación progreso y Salud in Seville and seeks to compare the effects of injecting different stem cells as therapy for critical ischemia in lower limbs in type 2 diabetic patients. Participants must have non-healing ulcers older than four weeks and no potential for conventional treatment (eg revascularisation). Participants will be randomly allocated into groups receiving randomised to receiving either their own bone marrow stem cells; mesenchymal stem cells from their fat, or their own selected bone marrow stem cells (CD 133+ stem cells). The cells will be delivered directly into the artery of the affected limb. Participants will be monitored for complications and assessed for changes in their clinical condition. The study commenced in July 2011 and expects to enrol 48 patients.