Stroke

Stem cells from fat, cord blood and bone marrow are being investigated as possible treatments for stroke. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Stroke

  • Autologous Hematopoietic Stem Cell Transplantation in Ischemic Stroke Location: China
    Overview: This trial at the Zheijang University Hospital seeks to investigate whether blood stem cells can aid recovery following stroke. The trial has designed to compare the neurological recovery in two groups of patients that have suffered a stroke (ischaemic stroke also referred to as cardiovascular accident). Participants will be randomly divided into a control group where they will only receive conventional medical therapy; or a ‘treatment’ group where they will receive blood stem cells (haematopoietic stem cells) as well as conventional medical therapy. The blood stem cells will be obtained from the patient’s blood following an injection of a drug (G-CSF) that releases stem cells from the bone marrow into the circulating blood.  The stem cells will then be transplanted directly into the damaged area of the brain via the cerebral artery. The trial commenced in January 2012.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Feasibility Study of Umbilical Cord Blood Mononuclear Cells Transplant to Treat Ischemic Stroke Location: China
    Overview: This trial aims to evaluate the safety and effectiveness of using a product made umbilical cord blood in Stroke. The trial is being conducted at four major hospital centres in Hong Kong by the China Spinal Injury Network and StemCyte Inc. The trial proposes to recruit 12 subjects who have had an ischaemic stroke (cardiovascular accident). Participants will be randomly divided into a group receiving only conventional treatment for stroke (control group); and a group receiving an injection of a proprietary product made from donate umbilical cord blood, in addition to the conventional treatment (experimental group). Participants will be monitored for complications and for changes in clinical condition. The trial commenced in October 2013 and is expected to be completed by March 2016.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Umbilical Cord Blood in the Treatment of Stroke in Children Location: US
    Overview: This trial aims to evaluate the safety and effectiveness of using cord blood to treat babies that have suffered a stroke. The trial is being conducted by the Children's Memorial Hermann Hospital and the University of Texas Health Science Centre, in conjunction with Cord Blood Registry Inc. Once diagnosed with having had a stroke around the time of birth (perinatal arterial ischaemic), the baby will be enrolled into the trial for transfusion with its own umbilical cord blood, provided this is available. The children will be monitored for complications and the clinical progress of each participant will be monitored for the next two years. The trial proposes to recruit 10 subjects between September 2012 and December 2015.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • The Stem Cell Application Researches and Trials In NeuroloGy-2 Study Location: South Korea
    Overview: This trial aims to determine if receiving their own stem cells immediately after a stroke can be of benefit to patients. The trial is being conducted at the Sungkyunkwan University School of Medicine and Samsung Medical Centre in Seoul in conjunction with Pharmicell Ltd. Participants will be randomly divided into either a control group which will receive standard treatment only, and an experimental group that will receive their own stem cells obtained from bone marrow and expanded in the laboratory. Participants will be monitored for complications and changes in clinical condition. The trial is scheduled to run from November 2012 to February 2016 and proposes to recruit 60 patients in the acute phase of an ischaemic stroke.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Phase II Clinical Trial to Evaluate the Feasibility and Safety of Human Adipose Derived Mesenchymal Stem Cells on Chronic Ischaemic Stroke Location: Spain
    Overview: This trial is evaluating the safety and effectiveness of fat stem cells in patients following stroke. The trial is being conducted at the Fundación para la Investigación Biomedical del Hospital Clínico San Carlos in Madrid and proposes to recruit 20 patients. All participants will be treated by injections directly into their brains (intracerebral injections) of expanded stem cells from their own fat. Participants will be monitored for complications and assessed for changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells