This trial aims to investigate the use of the patient's mesenchymal stem cells in the treatment of nephropathy and kidney failure in patients with type 1 diabetes. The trial is being conducted by the Endocrinology and Metabolism Research Institute in Teheran and proposes to recruit 20 patients by end 2013. The participants will receive an intravenous infusion of mesenchymal stem cells obtained from their own bone marrow and expanded in the laboratory. Participants will be monitored for complications and changes in their condition.