This trial is investigating the safety, feasibility and effectiveness of neural stem cell transplantation in treating Motor Neurone Disease (or Amyotrophic Lateral Sclerosis). The trial is being conducted at the Azienda Ospedaliera Santa Maria in Terni in conjunction with Università di Padova. Participants will be treated with neural stem cells, obtained from donated foetal tissue, which will be implanted in the spinal cord. Participants will be monitored for complications and changes in their clinical condition. The trial proposes to enrol 18 patients between December 2011 and September 2016.