This trial is evaluating the stem cells derived from bone marrow in treating patients with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS). The study is being conducted by the Royan Institute in Teheran and proposes to recruit 10 patients with MND between September 2012 and December 2013. Participants will have mesenchymal stem cells isolated from their own bone marrow and injected directly in their brains (intraventricularly injection). Participants will be monitored for complications and assessed for changes in their clinical condition. This study similar to another study (NCT01759797) also being performed at the Royan Institute on patients with MND although the route of administration of the cells is intravenous.