Cerebral Palsy

Stem cells from cord blood and bone marrow are being investigated as possible treatments for cerebral palsy. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Cerebral Palsy

  • Umbilical Cord Blood Therapy for Cerebral Palsy Location: South Korea
    Overview: This trial seeks to investigate the effect of donated umbilical cord blood stem cell in the treatment of cerebral palsy. Participants were divided into a treatment group that received an infusion of cord blood and rehabilitation, and a control group that also received rehabilitation and an injection but no cord blood. Patients, caregivers and researchers did not know what group they were in. Both groups were assessed for improvements in neurological function such as the Gross Motor Performance Measure, the Korean Bayley Scale of Infant Development, visual perception, muscle strength and brain glucose utilisation. The study recruited 37 patients with cerebral palsy (aged between 6 months and 20 years) and was conducted at the CHA University Medical Centre in the Republic of Korea.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Completed
    Stem Cell: Umbilical Cord Stem Cells
  • Effect of Autologous Neural Stem Cells Transplantation on Patients with Cerebral Palsy Location: China
    Overview: This trial is being conducted at the Zhejiang Armed Police Hospital in Jiaxing. The trial involves comparing participants treated with their own bone marrow stem cells (experimental arm) with a similar group of cerebral palsy patients receiving a placebo transplant (control arm). The treatment involves an injection directly into the brain (intracranial injection). The trial commenced in January 2010 with a plan to enrol 30 participants in each group by July 2012. The subjects are being assessed for changes in motor and language skills.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Comparative Analysis of Curative Effect of Autologous Bone Marrow Mesenchymal Stem Cell Transplantation and Autologous Mononuclear Bone Marrow Cells Treating Cerebral Paralysis Location: China
    Overview: This trial aims to different types of stem cells for the treatment of cerebral palsy. The trial is being conducted at the General Hospital of the People's Armed Police Forces Hospital in Beijing and proposes to recruit 60 patients with cerebral palsy (with MRI evident white-matter hyperplasia). Participants will be randomly divided between three groups. One group will receive intravenous (IV) infusions of mesenchymal stem cells derived from their own bone marrow. A second group will receive a different type of bone marrow cell (mononuclear cells). The third group will only receive conventional treatment (the control group). Participants will be monitored for complications and changes in clinical condition. The trial was scheduled to complete in December 2012 but it is unclear if results have been published.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Effectiveness of Cord Blood Stem Cell Infusion for the Treatment of Cerebral Palsy in Children Location: US
    Overview: This trial is designed to evaluate the use of cells from cord blood for the treatment in children who have motor disability due to cerebral palsy. The trial is being conducted by Georgia Health Sciences University and Georgia Regents University. Participants must have their own cord blood stored and be older than two years of age (and up to 12 years of age). Participants will be divided into two groups. The first group will receive their cord blood intravenously (via IV). The second group will initially receive a sham injection but will then receive their cord blood. Neither the children, their carers or their doctors will know which group they are in (observer-blinded crossover investigation). Participants will be monitored for complications, as well as changes in their clinical condition. The trial and expects to enrol 40 subjects with the study estimated to be completed February 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Safety and Efficacy of Bone Marrow Derived Autologous Cells Treatment of Cerebral Palsy in Subjects Above 15 Years Location: India
    Overview: This trial is designed to evaluate the use of the patient’s own bone marrow cells for the treatment of cerebral palsy. The trial is being conducted by Chaitanya Hospital in Pune and expects to enrol 100 subjects (older than 15 years) by April 2014. Participants will receive mesenchymal stem cells from their own bone marrow injected directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Multiple Transplantation of Bone Marrow Derived CD133 Cell in Cerebral Palsy Location: Iran
    Overview: This trial is designed to evaluate the use of the patient’s own blood stem cells for the treatment of cerebral palsy. The trial is being conducted by the Royan Institute in Tehran and expects to enrol 24 subjects by April 2014. Participants will receive cell from their own bone marrow (CD133+ cells) in multiple injections directly into the fluid around spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Efficacy of Bone Marrow MNC for the Treatment of Cerebral Palsy in Subjects Below 15 Years Location: India
    Overview: This trial is designed to evaluate the use of the patient’s own bone marrow cells for the treatment of cerebral palsy. The trial is being conducted by Chaitanya Hospital in Pune and expects to enrol 100 subjects (younger than 15 years) by March2014. Participants will receive mesenchymal stem cells from their own bone marrow injected directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells