Motor Neurone Disease

Stem cells from cord blood, bone marrow and foetal tissue are being investigated as possible treatments for Motor Neurone Disease (also known as Amyotrophic Lateral Sclerosis or ALS). Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Motor Neurone Disease

  • Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Location: Italy
    Overview: This trial is investigating the safety, feasibility and effectiveness of neural stem cell transplantation in treating Motor Neurone Disease (or Amyotrophic Lateral Sclerosis). The trial is being conducted at the Azienda Ospedaliera Santa Maria in Terni in conjunction with Università di Padova. Participants will be treated with neural stem cells, obtained from donated foetal tissue, which will be implanted in the spinal cord. Participants will be monitored for complications and changes in their clinical condition. The trial proposes to enrol 18 patients between December 2011 and September 2016.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Foetal Stem Cells
  • Intravenous Transplantation of Mesenchymal Stem Cell in Patients with ALS Location: Iran
    Overview: This trial aims to investigate the use of the patient's own bone marrow stem cells in treating patients with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS). The trial is being conducted by the Royan Institute in Teheran and proposes to recruit 10 patients between September 2012 and December 2013. Participants will have bone marrow stem cells harvested, separated and infused intravenously. Participants will be monitored for complications, as well as changes in their clinical condition. This study is similar to another study also being performed at the Royan Institute (NCT01759784) on MND patients except that the mesenchymal stem cells are administered directly into the brain (intraventricular injection).
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Intraventricular Transplantation of Mesenchymal Stem Cell in Patients with ALS Location: Iran
    Overview: This trial is evaluating the stem cells derived from bone marrow in treating patients with Motor Neurone Disease (MND) or Amyotrophic Lateral Sclerosis (ALS). The study is being conducted by the Royan Institute in Teheran and proposes to recruit 10 patients with MND between September 2012 and December 2013. Participants will have mesenchymal stem cells isolated from their own bone marrow and injected directly in their brains (intraventricularly injection). Participants will be monitored for complications and assessed for changes in their clinical condition. This study similar to another study (NCT01759797) also being performed at the Royan Institute on patients with MND although the route of administration of the cells is intravenous.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • The Clinical Trial on the Use of Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Location: China
    Overview: This trial is designed to evaluate the use of umbilical cord mesenchymal stem cells for motor neurone disease. The trial is being conducted at General Hospital of Chinese Armed Police Forces in Beijing. Participants will receive multiple transplants of the cells via lumbar puncture. Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 30 subjects by invitation only.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Not Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis Location: US
    Overview: This trial is designed to evaluate the use of the donated spinal stem cells for the treatment of motor neurone disease. The trial is being conducted by Emory University in Georgia, in conjunction with Neuralstem Inc. The stem cells used in the study were obtained from donated foetal tissue. Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 10 subjects by June 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Not Recruiting
    Stem Cell: Foetal Stem Cells
  • Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis Location: US
    Overview: This trial is designed to evaluate the use of the donated spinal stem cells for the treatment of motor neurone disease. The trial is being conducted by Emory University in Georgia and University of Michigan, in conjunction with Neuralstem Inc. Participants will receive different doses of the cells which were obtained from donated foetal tissue. Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 18 subjects by February 2014 by invitation only.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Foetal Stem Cells
  • Clinical Trial on The Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis Location: Spain
    Overview: This trial is designed to evaluate the use of the patient’s own blood stem cells for the treatment of motor neurone disease. The trial is being conducted by Hospital Universitario Virgen de la Arrixaca in conjunction with Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia. Participants will be divided into three groups. The first experimental group will receive stem cells obtained from their own bone marrow directly into the spinal cord via a laminectomy (T3-T4). The second experimental group will receive their stem cells into the fluid around their spinal cord (intrathecal injection). The third group will be a control group and will receive an intrathecal injection. Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 63 subjects by October 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALS Location: Iran
    Overview:

    This trial is designed to evaluate the use of the patient’s own blood stem cells for the treatment of motor neurone disease. The trial is being conducted by the Royan Institute in Tehran and expects to enrol 10 subjects by December 2013. Participants will receive mesenchymal stem cell from their own bone marrow injected directly into their brain (intraventricular injection). Participants will be monitored for complications, as well as changes in their clinical condition.

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis Location: Korea
    Overview:

    This trial is designed to evaluate the use of donated blood stem cells for the treatment of motor neurone disease. The trial is being conducted by the Hanyang University Seoul Hospital, in conjunction with Corestem Inc. Participants will receive stem cells from partially matched donated bone marrow (HLA-haplo matched Allogenic Bone Marrow) directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 18 subjects by December 2013. 

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis Location: US
    Overview: This trial is designed to evaluate the use of the patient’s own blood stem cells for the treatment of motor neurone disease. The trial is being conducted by the Mayo Clinic in Minesota and expects to enrol 25 subjects by May 2014. Participants will receive different doses of mesenchymal stem cell from their own bone marrow injected directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells