Spinal Cord Injury

Stem cells from fat, cord blood, bone marrow and foetal tissue are being investigated as possible treatments for Spinal Cord Injury. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Spinal Cord Injury

  • The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Transplantation in Spinal Cord Injury Patients Location: China
    Overview: This trial aims to investigate transplantation of umbilical cord stem cells from patients with paraplegia. The study is being conducted at the General Hospital of Chinese People's Armed Police Forces in Haidian. Stem cells derived from donated umbilical cord blood will be given to the trial participants via the femoral artery. The trial expect to enrol 20 patients with traumatic paraplegia [levels T10 through to L2] between April 2012 and December 2013. Participants will be assessed for complications and for improvement in functions such as bladder contracting capacity as well as sensory responsiveness.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Intrathecal Transplantation Of Autologous Adipose Tissue Derived MSC in the Patients with Spinal Cord Injury Location: South Korea
    Overview: This trial is investigating the effects of stem cells from the patient's own fat in the treatment of chronic spinal cord injury. The trial is being conducted at the Korea University Anam Hospital in Seoul and plans to recruit 15 participants. The fat stem cells will be injected into the fluid surrounding the spinal (intrathecal injection) three times over approximately two months. Participants will be monitored for complications and assessed for changes in neurological and sensory function. The trial is expected to complete in December 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Phase 1/2 Study of Treatment for Spinal Cord Injury with Autologous Mononuclear Cells Derived from Bone Marrow Location: Japan
    Overview: This trial is investigating the effects of a single injection of the patient's own bone marrow stem cells in patients for spinal cord injury. The trial is being conducted by the Kitano Hospital in Osaka. Participants will be treated with a single injection of their own bone marrow stem cells directly into the fluid surrounding the spinal cord around 3-52 weeks after their spinal injury. The trial commenced in March 2012.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Efficacy of Autologous Mesenchymal Stem Cells in Chronic Spinal Cord Injury Location: South Korea
    Overview: This trial aims to evaluate the safety and effectiveness of the patient's own bone marrow stem cell in chronic spinal cord injury. The trial is being conducted by the Asian Medical Centre in Seoul in conjunction with biotech Pharmicell Co Ltd. The trial expects to enrol 32 patients with chronic spinal cord injury between August 2008 and September 2014. This trial follows on from a phase 1 trial that established the safety of the procedure. Participants will be injected with their own cells that have been obtained from bone marrow and expanded in the laboratory. The cells will be injected into the fluid surrounding the spinal cord following spinal surgery (posterior cervical laminectomy). Participants will be monitored for complications and changes in motor and sensory function.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Autologous Mesenchymal Stem Cells in Spinal Cord Injury Patients Location: Chile
    Overview: This trial aims to evaluate the effects of the patient's own bone marrow stem cells were injected in spinal cord injury. The trial is being conducted at the Clinica las Condes in Chile and seeks to enrol 30 participants by January 2014. Participants will receive mesenchymal stem cells obtained from the patient's bone marrow and expanded in the laboratory. From the listing in the registry, it is unclear how the cells will be delivered to the patient. Safety of the procedure is cited as the primary outcome and functional improvement in muscle and sphincter control as the secondary outcome.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Clinical Observation on the Therapeutic Effect of Bone Marrow Mesenchymal Stem Cell on Patients with Spinal Cord Injury Location: China
    Overview: This trial aims to investigate the effect if any, of the patient's own bone marrow stem cells quadriplegic patients. The trial is being conducted at General Hospital of Chinese People's Armed Police Forces in Beijing and seeks to enrol 40 patients who have had C4-6 level complete quadriplegia for at least one year. Participants will be divided into an experimental group who will receive mesenchymal stem cells obtained from their own bone marrow by an open surgical transplantation. The other participants will receive no intervention. Participants will be monitored for complications and changes in their condition, including bladder function. This institute has also conducted a similar trial (ChiCTR-ONC-12002005) in paraplegics.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Completed
    Stem Cell: Adult Bone Marrow Stem Cells
  • Efficacy and Safety of Local Stem Cell Transplantation for Sequelae of Spinal Cord Injury Location: China
    Overview: This trial was conducted to evaluate the role of the patient's own bone marrow stem cells for spinal cord injury. The trial was conducted at General Hospital of Chinese People's Armed Police Forces in Beijing and sought to whether giving the participants the stem cells via intravenous (IV) infusion was any different to delivering the cells by surgical transplantation directly at the site of the lesion. The trial sought to recruited 27 subjects with Spinal Cord Injury by February 2012. Nine of these subjects underwent an open surgical transplantation with mesenchymal stem cells from the patient's bone marrow, whilst another nine received an intravenous infusion of their mesenchymal stem cells. A final group of nine was the control group which did not receive cells. There does not appear to be any other information regarding experimental protocol, trial outcomes or results available.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Completed
    Stem Cell: Adult Bone Marrow Stem Cells
  • To Study the Safety and Efficacy of Autologous Bone Marrow Stem Cells in Patients With Spinal Cord Injury (ABSCI) Location: India
    Overview: This trial aims to evaluate the safety and effectiveness of stem cells from the bone marrow in patients with chronic spinal cord injury. The trial is being conducted by Max Institute of Neurosciences in Uttrakhand and proposes to recruit 15 patients between November 2012 and November 2014. Participants will have an injury established at C5 or below and will receive an injection of their own bone marrow stem cells into the fluid surrounding the spinal cord (intrathecal injection). Participants will be monitored for complications and changes in clinical condition, including changes in standard neurological and functional scores.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Long-Term Follow-Up of Transplanted Human Central Nervous System Stem Cells in Spinal Cord Trauma Subjects Location: US
    Overview: This is an observational study to follow 12 paraplegics who received surgical transplantation of their donated stem cells. The study is a long-term follow-up of the participants in the Phase I/II Safety and Preliminary Efficacy Investigation of Intramedullary Spinal Cord Transplantation sponsored by Stem Cells Inc at the Uniklinik Balgrist in Zurich. The participants received the proprietary product HuCNS-SC® made from donated foetal tissue and will be monitored for complications and changes in their clinical condition for a further six years until March 2018.
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Not Recruiting
    Stem Cell: Foetal Stem Cells
  • Autologous Stem Cells for Spinal Cord Injury in Children Location: US
    Overview: This trial is designed to evaluate the use of the patient’s own bone marrow cells for the treatment of Spinal Cord Injury in children. The trial is being conducted by Children's Memorial Hemann Hospital in conjunction with The Institute for Rehabilitation and Research Foundation; The University of Texas Health Science Center; M.D. Anderson Cancer Center and the Baylor College of Medicine. Participants will receive cells from their own bone marrow (Bone Marrow Progenitor Cells) injected directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 10 subjects by April 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Mesenchymal Stem Cells Transplantation to Patients With Spinal Cord Injury Location: China
    Overview: This trial is designed to evaluate the use of the patient’s own bone marrow cells for the treatment of Spinal Cord Injury. The trial is being conducted by Guangzhou General Hospital of Guangzhou Military Command in Guangdong and expects to enrol 20 subjects. Participants will receive mesenchymal stem cells from their own bone marrow injected directly into the fluid surrounding their spinal cord (intrathecal injection) and into their veins (intravenous injection). Participants will be monitored for complications, as well as changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI Location: US
    Overview:

    This trial is designed to evaluate the use of donated spinal cord nerve stem cells for the treatment of Spinal Cord Injury. The trial is being conducted by University of Miami; Shepard Center in Georgia; Thomas Jefferson University Hospital in Philadelphia; and Medical College of Wisconsin, in conjunction with Neuralstem Inc. Participants will receive different doses of human spinal cord stem cells obtained from donated foetal tissue. The cells will be injected into the injured part of the spinal cord as part of a surgical procedure (laminectomy or laminoplasty). Participants will be monitored for complications, as well as changes in their clinical condition. The trial expects to enrol 8 subjects by December 2013 but is not yet accepting participants.

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Foetal Stem Cells
  • Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Spinal Cord Injury Location: India
    Overview:

    This trial is designed to evaluate the use of the patient’s own bone marrow cells for the treatment of Spinal Cord Injury. The trial is being conducted by Chaitanya Hospital in Pune and expects to enrol 50 subjects by March 2014. Participants will receive mesenchymal stem cells from their own bone marrow injected directly into the fluid surrounding their spinal cord (intrathecal injection). Participants will be monitored for complications, as well as changes in their clinical condition. 

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With Spinal Cord Injury Location: South Korea
    Overview:

    This trial is designed to evaluate the use of cells from the patient’s own fat for the treatment of Spinal Cord Injury. The trial is being conducted by Korea University Anam Hospital in Seoul, in conjunction with RNL Bio Company Ltd. Participants will receive different doses of mesenchymal stem cells from their own fat injected directly into their veins (intraveneous injection). Participants will be monitored for complications, as well as changes in their clinical condition. The trial and expects to enrol 15 subjects by April 2014.

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells