Bone repair

Stem cells from fat and bone marrow are being investigated as possible treatments for bone repair. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Bone repair

  • Clinical Observation of the Porous Tantalum Implantation Combined with Autologous Bone Marrow Stem Cell Transplantation for the Treatment of Osteonecrosis Location: China
    Overview: This study was conducted at the Daping Hospital in Chongqing and investigated the effect of using the patient's own bone marrow stem cells in repairing osteonecrosis at the top of the thigh bone (head of femur). In the study, participants were enrolled into control and test groups. The control group received an implant made from tantalum to correct the osteonecrosis at the top of the thigh. The test group received the same implant but also their bone marrow stem cells. Fifty participants were enrolled in the study that completed in October 2012. The results of this trial do not appear to have been published.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Mesenchymal Stem Cells in Osteonecrosis of the Femoral Head Location: Spain
    Overview: This trial is investigating whether donated bone marrow stem cells can aid recovery following surgery for avascular necrosis of the femoral head. This study is being conducted at the Hospital Universitari Vall d'Hebron in Barcelona in conjunction with the Spanish Blood and Tissue Bank (Banc de Sang i Teixits). The trial expects to recruit 24 participants with avascular necrosis of the femoral head between July 2012 and December 2014. The subjects will be randomly assigned to a control group which will receive standard treatment, or an experimental group that will have a transplant of a proprietary product that is an donated bone matrix impregnated with donated bone marrow derived stem cells (XCEL-MT-OSTEO-ALPHA). Participants will be monitored for complications and for changes in bone growth and pain levels.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Donor and Role in Management and Reconstruction of Nonunion Fracture Location: Indonesia
    Overview: This trial is designed to investigate if adding stem cells can assist in bone repair. The trial being conducted by the Indonesia University in Jakarta and proposes to recruit 10 participants with fractures that have failed to heal. The control group will receive an bone graft from their hip, whereas the experimental group will receive bone marrow stem cells that have been expanded in the laboratory (mesenchymal stem cells) at the fracture site as well as bone matrix (hydroxyapatite matrix). Participants will be monitored for complications and fracture repair. The trial is expected to complete in January 2016.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Use of Chondrocytes Cells for Bone Growth Plate Injury in Children Location: India
    Overview: This pilot clinical study is investigating the efficacy of the patient's own stem cells in repairing damaged growth plate of long bones in children. The small trial is being conducted by the Christian Medical College Vellore in Tamil Nadu and proposes to enrol five children who have sustained permanent damage to the epiphyseal growth plate of a long bone. Bone marrow stem cells will be harvested from the participant's hip (iliac crest), expanded in a laboratory and surgically implanted into the growth plate after the scar tissue has been removed. Bone growth will be measured at three monthly intervals for 2 years. The study commenced in March 2012 and is expected to run to March 2014.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Distraction Osteogenesis with Culture Expanded Bone Marrow Cells for Patients with Skeletal Dysplasias and Short Stature Location: Japan
    Overview: This trial is investigating the use of bone marrow stem cells in creating new bone growth in surgery for bone lengthening. The trial is being conducted by Nagoya University Hospital. Prior to surgery for bone lengthening, bone marrow will be harvested from participants and stem cells isolated and expanded. These stem cells will then be introduced to the fracture site at the time of surgery. Participants will be monitored for complications and assessed for bone repair. The trial expects to enrol 30 subjects.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient with Avascular Necrosis of the Femoral Head Location: South Korea
    Overview: This trial is investigating the safety and effectiveness using the patient's own fat stem cells in the treatment of avascular necrosis of the femoral head. The trial is being conducted by the SMG-SNU Boramae Medical Center in Seoul, in conjunction with RNL Bio Co Ltd. Participants will have stem cells obtained from their own fat transplanted into the femoral head. Participants will be monitored for complications and changes in their clinical condition. The trial seeks to enrol 15 participants with between May 2012 and July 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Phase II Clinical Trial Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem Cells Location: Spain
    Overview: This trial is evaluating the safety and effectiveness of using the patient's own mesenchymal stem cells in treatment of osteonecrosis of the femoral head. The trial is being conducted by the University Hospital of Salamanca and Red de Terapia Celular and proposes to enrol 10 participants. All participants will be treated with mesenchymal stem cells that have been obtained from their own bone marrow and expanded in the laboratory. The trial started in July 2012.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • The Combined Effect of Mesenchymal Stem Cell, HA-CaSO4,BMP-2, and Implant in Inducing the Healing of Critical-Sized Bone Defect Location: Indonesia
    Overview: This trial aims to evaluate whether any of several different approaches using mesenchymal stem cells can assist in bone repair. The trial is being conducted by the University of Indonesia in conjunction with the National University of Singapore and aims to enrol five participants between November 2012 and December 2014. The trial will compare treatment involving mesenchymal stem cells, the factor HA-CaSO4, the factor BMP-2, and an implant in treating critical-sized (> 2.5 cm) bone defects. Participants will be monitored for complications and changes in clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials Location: Australia
    Overview: This pilot study aims to demonstrate the safety and effectiveness of using the patient's own mesenchymal stem cells in cranial reconstruction. The trial being conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015 and expects to enrol 10 participants who require cranial reconstruction as a result of surgery or trauma. This trial proposes to use an implant that is customised to match the skull defect and is a sandwich of a scaffold embedded with mesenchymal stem cells that have been harvested from the patient and expanded in the laboratory. It is expected that the stem cells will multiply to occupy the scaffold with bone generating cells, which will eventually replace the entire scaffold with new bone. Participants will be assessed for complications. Bone formation will be monitored by CT scanning.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells