Intervertebral disc degeneration

Stem cells from fat and bone marrow are being investigated as possible treatments for disc repair. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Intervertebral disc degeneration

  • Clinical Trial Based on the Use of Mesenchymal Stem Cells From Autologous Bone Marrow in Patients With Lumbar Intervertebral Degenerative Disc Disease Location: Spain
    Overview: This study being undertaken by Red de Terapia Cellular and the University Hospital of Salamanca to investigate whether stem cells from the patient's bone marrow can improve outcomes following back surgery. The study involves collecting mesenchymal stem cells from the patient’s bone marrow and expanding these cells in the laboratory. The cells are then transplanted during back surgery. Participation is by invitation only and restricted to patients lumbar intervertebral degenerative disc disease. The trial started in January 2010 and is expected to enrol 15 patients.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety Study of Mesenchymal Stem Cells and Spinal Fusion Location: Spain
    Overview: This trial is being conducted at five centres in Spain by the Banc di Sang I Teixits and seeks to investigate whether the patient’s own stem cells can assist in recovery following back surgery. Participants with L4-5 spinal degenerative disease requiring fusion surgery will be assigned to either the control group where they will receive a bone graft during surgery, or the treatment group where they will receive their own mesenchymal stem cells. The stem cells will be collected from the patient’s bone marrow and expanded in the laboratory before they are used. Participants will be assessed for complications following treatment and for improvements in their condition using standard tests including radiography and tomography as well as a subjective patient symptom and disability scores. The trial is expected to enrol 62 patients and be completed by November 2014.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient with Lumbar Intervertebral Disc Degeneration Location: South Korea
    Overview: This trial is investigating the safety and effectiveness of using the patient's own fat cells for repair of disc degeneration. The trial is being conducted at the Korea University Anam Hospital in conjunction with RNL Bio Co Ltd and proposes to enrol eight patients with back pain due to intervertebral disc degeneration. All participants will receive mesenchymal stem cells that had been previously harvested from their own fat. The cells will be delivered by an injection directly into the affected disc. Participants will be monitored for complications and changes in their clinical condition. The trial commenced in July 2012 and is expected to be completed in 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Fatty Tissue Stem Cells