Osteoarthritis

Stem cells from fat and bone marrow are being investigated as possible treatments for Osteoarthritis. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Osteoarthritis

  • The Effects of Intra-articular Injection of Mesenchymal Stem Cells in Knee Joint Osteoarthritis Location: Iran
    Overview: This trial conducted at Royan Institute in Teheran investigated the effects of injecting the patient's own bone marrow stem cells into the knee joints of 40 patients with severe osteoarthritis. The proposed primary outcome measure was to assess any difference in the subjects' functional abilities and pain score at two different time points (two weeks and three months after the injection of stem cells). The study was conducted between September 2010 and November 2012.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Completed
    Stem Cell: Adult Bone Marrow Stem Cells
  • Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells (MSV_allo) Location: Spain
    Overview: This trial aims to investigate the effect of cells from bone marrow on osteoarthritis of the knee. The trial is being undertaken at two centres by Centro Medico Tecnon in Barcelona and Hospital Clinico Universitario in Valladolid, in conjunction with a biotechnology firm Red Terapia de Cellular. The trial is designed to recruit a total of 30 subjects from April 2012 to December 2013 with documented Grade II, III and IV osteoarthritis. Participants will be enrolled in either the control arm where they will receive injections into the joint (intra-articular injections) of hyaluronic acid; or they will be enrolled in the treatment arm where they will receive injections into the joint of a preparation of bone marrow mesenchymal stem cells. The cells that have been harvested from healthy donors and expanded in the laboratory. The participants will be monitored for complications and any improvement of their osteoarthritis using standard assessments including MRI imaging of cartilage thickness.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Outcomes Data of Bone Marrow Stem Cells to Treat Hip and Knee Osteoarthritis Location: US
    Overview: This study is investigating the effect of the patient’s own bone marrow in patients suffering from osteoarthritis of the knee and hip. The study is being conducted by the Regenerative Pain Centre in Des Plaines Illinois and seeks to enrol 15 patients. There is no control group in this study. Participants will be assessed for knee and hip function.
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • ADIPOA - Clinical Study Location: France and Germany
    Overview: This trial aims to evaluate the safety and effectiveness of different doses of the patient's own fat stromal cells in the treatment of severe osteoarthritis of the knee joint. The study is being undertaken at the University Hospital Montpelier in France and at the Orthopädische Klinik in Wurzburg, Germany. The study plans to enrol a total of 18 subjects with moderate to severe osteoarthritis of the knee, at both centres between April 2000 trial and April 2014. Stromal cells will be harvested from fat obtained by liposuction of the subjects and injected into their knees. The subjects will be divided into three groups that receive three strengths concentrations of cells. Participants will be monitored for complications and assessed for changes in their clinical condition. The study is expected to be completed by April 20015.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Adipose-Derived Stem Cells in Patients with Knee Osetoarthritis Location: Australia
    Overview: This trial aims to compare the effect of the patient's own fat stem cells in the treatment of osteoarthritis of the knee. The trial is being conducted by the Lakeside Medical Centre in Albert Park and the Australian Catholic University in Melbourne. The trial that has not started yet according to the registration information, but proposes to recruit 60 patients. Participants will be randomly assigned into two different categories. One group will receive an injection of hyaluronic acid derivative (Hylan GF). Another group will receive a suspension of cells derived from liposuction. The information provided on the ANZCTR indicates that the subjects will receive three injections but does not provide further details about the preparation of the cells. Participants will be monitored for complications and assessed for changes in their clinical condition.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Evaluation of mesenchymal stem cells in the treatment of knee osteoarthritis – A randomised Controlled Trial Location: Australia
    Overview: This study seeks to assess the response of osteoarthritis of the knee to different dosing and injection protocols of adipose-derived (liposuction) mesenchymal stem cells collected from the participant (autologous). 40 participants will be enrolled in the Melbourne study and randomly separated into either one of three treatment groups or a control group receiving conservative management. If the treatment groups show significant and conclusive improvements the control group will be offered cross over at 12months. This study is funded and there will be no treatment charge to the participants.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells