Chronic wounds and ulcers

Stem cells from bone marrow are being investigated as possible treatments to assist in chronic wound healing. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Chronic wounds and ulcers

  • Safety Study of Stem Cells Treatment in Diabetic Foot Ulcers Location: Israel
    Overview: This trial aims to investigate the safety of using mesenchymal stem cells obtained from donated bone marrow in the treatment of chronic diabetic leg ulcers. The trial is being conducted by the Sheba Medical Centre and plans to enrol 20 patients with chronic diabetic leg ulcers which have proved difficult to heal and are smaller than 10 cm². During one sitting, all the participants will receive multiple injections of donated mesenchymal stem cells in the affected limb as well as in the ulcer bed. Participants will be monitored for complications and for ulcer. The trial is expected to conclude in 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Cell Therapy for Venous Leg Ulcers Pilot Study Location: Uruguay
    Overview: This trial aims to investigate the use of the patient's own bone marrow stem cells in the treatment of chronic non-healing leg ulcers. The trial is being conducted at the Universidad de la República and the Hospital de Clínicas Dr. Manuel Quintela in Montevideo. The trial expects to enrol six participants by December 2013. Participants will have stem cells from their bone marrow harvested and injected into around the ulcers. All participants will be monitored for complications following the procedure, and changes in clinical condition, including a reduction in the size of the ulcer.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Study of the Effectiveness of Autologous Bone Marrow-derived Mesenchymal Stem Cells in Fibrin to Treat Chronic Wounds Location: US
    Overview: This trial aims to investigate the use of mesenchymal stem cells from the patient's bone marrow in the healing of chronic wounds. The trial is being conducted at the Roger Williams Medical Centre on Providence Rhode Island and proposes to recruit 66 subjects with chronic non-healing wounds between June 2010 and December 2015. Participants will be randomly divided into three groups. A control group will only receive conventional treatment. A second group will receive conventional treatment and fibrin spray. The third group will receive conventional treatment, the fibrin spray mesenchymal stem cells from their own bone marrow. All participants will be monitored for complications following the procedure, and changes in clinical condition, including wound closure.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells