Cornea damage

Stem cells from the health part of the eye (limbal stem cells) are being investigated as possible treatments for damage to the cornea. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Cornea damage

  • Safety Study of Stem Cell Transplant to Treat Limbus Insufficiency Syndrome Location: Spain
    Overview: This trial is being conducted at the Instituto Universitario de Oftalmobiología Aplicada and the University of Valladolidto to investigate the safety and effectiveness of transplanting different donated stem cells in patients with Limbus Insufficiency Syndrome. In this condition, vision is limited due to ulceration and opacity of the cornea. Participants in the trial will be randomly assigned to a treatment group where they will receive donated stem cells from the eye (limbal epithelial stem cells), or a second treatment group where they will receive mesenchymal stem cells collected from donated bone marrow. Participants will be assessed for complications, survival of the grafted cells and changes in vision. The trial is expected to enrol 30 subjects and to complete in February 2014.
    Link to Clinical Registry
    Trial Design: Safety Study
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)
  • To Evaluate the Safety and Effectiveness of Human ex vivo Expanded Autologous Limbal Stem Cells for the Treatment of Unilateral Total Limbal Stem Cell Deficiency Location: UK
    Overview: This study is investigating the effect of transplanting the patient’s own limbal stem cells in cases where vision is affected in only one eye. The treatment involves taking a biopsy from the patient's unaffected eye (their 'good' eye) and growing these cells in the laboratory on a donated placental tissue (human amniotic membrane). The sheet of cells is then transplanted into the patient's affected eye. The trial is being conducted at the Institute of Health and Society in Newcastle upon Tyne and expects to enrol 24 subjects by November 2013. Participants will be assessed up to three years after treatment.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)
  • Ex vivo Expanded Corneal Limbal Stem Cell Transplantation Location: UK
    Overview: This trial aims to investigate the effect of donated limbal stem cells patients with corneal blindness. The trial is being conducted at the Princess Alexandra Eye Pavilion in Edinburgh, Scotland. Participants will be randomly assigned to either an experimental or a control group. The experimental group will be treated with a membrane from donated placenta (human amniotic membrane) containing donated limbal stem cells. The control group will be treated with the membrane only. Neither the doctors nor the participants will be aware of which treatment each subject has undergone. Participants will be assessed regularly over an 18 month period for complications and for improvement in vision and changes in the cornea. The trial commenced in February 2012 and expects to enrol 20 participants by December 2013.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)
  • Autologous Cultured Corneal Epithelium for the Treatment of Limbal Stem Cell Deficiency Location: Canada
    Overview: This trial aims to investigate the use of a cultured corneal epithelium graft from the unaffected eye of patients with Limbal Stem Cell Deficiency. The trial is being conducted at the Centre Hospitalier Universitaire de Québec, Quebec and proposes to recruit 15 patients between December 2012 and December 2017. Biopsies from the unaffected eye will be cultured and used as a stem cell corneal transplant in the affected eye. All participants will be monitored for complications following the procedure, and changes in clinical condition, including improvements in corneal opacity, vascularisation and integrity of the epithelial surface.
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)
  • Epithelial Cell Transfer for Severe Corneal Disease Location: Australia
    Overview: This trial aims to evaluate a new contact lens system to culture and transfer limbal stem cells to the corneal surface in patients with limbal stem cell deficiency. The trial is being conducted by the the School of Medical Sciences at the University of New South Wales. Limbal stem cells will be harvested from the patient unaffected eye and will then be cultured on specially designed contact lens, before being transferred to the patient's cornea. Participants will be monitored for complications and assessed for changes in their clinical condition, including examination of ocular health and corneal epithelium integrity. The trial started in May 2007 and expects to recruit 30 patients with limbal stem cell deficiency.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)