Macular Degeneration

Stem cells from bone marrow, embryonic stem cells and foetal tissue are being investigated as possible treatments for macular degeneration. Click on the link provided to find out more about each trial. It remains too early to know which approach will be most suitable. We need evidence collected in clinical trials to determine if a proposed stem cell treatment is both safe and effective.

tagged as Macular Degeneration

  • A Phase I/IIa, Open-Label, Single-Center, Prospective Study to Determine the Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial Cells in Patients With Advanced Dry Age-related Macular Degeneration Location: South Korea
    Overview: This trial is designed to evaluate the safety and effectiveness of transplanting retinal pigment epithelial cells (RPE) in patients with Age Related Macular Degeneration. The trial is being conducted at the Bundang Medical Center in Gyeonggi-do in conjunction with CHA Bio and Diostech at several centers. Participants will be divided into four groups – each of which will receive different doses of cells. The cells used in the trial have been obtained from human embryonic stem cells. Participants will be monitored for complications including infection and tumour growth, as well as structural evidence of successful engraftment and changes to vision. The trial expects to enrol 12 subjects between September 2012 and April 2016.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Embryonic Stem Cells
  • Study of Human Central Nervous System Stem Cells in Age-Related Macular Degeneration Location: US
    Overview: This trial is designed to evaluate the use of nerve stem cells in patients with Age Related Macular Degeneration. The trial is being conducted at the Byers Eye Institute at Stanford, Stanford Hospital and Clinics in conjunction with StemCells Inc. Participants will be divided into two groups with the stem cells provided in different doses. The cells used in the trial have been obtained from foetal tissue (referred to as HuCNS-SC cells) and will be transplanted under the retina of one eye. Participants will be monitored for complications as well as structural evidence of successful engraftment and changes to vision. The trial expects to enrol 16 subjects.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Foetal Stem Cells
  • Intravitreal Bone Marrow-Derived Stem Cells in Patients With Advanced Age-related Macular Degeneration Location: Brazil
    Overview: This trial is designed to evaluate the use of the patient’s own bone marrow stem cells to treat Age Related Macular Degeneration. The trial is being conducted by the University of Sao Paulo and expects to enrol 10 subjects by September 2013. Participants will have the stem cells injected directly into their eye (intravitreal injection). Participants will be monitored for complications as well as structural evidence of successful engraftment and changes to vision.

     

    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • A Study Of Implantation Of Human Embryonic Stem Cell Derived Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration Location: UK
    Overview: This trial is designed to evaluate the safety and effectiveness of transplanting retinal pigment epithelial cells (RPE) in patients with wet age-related macular degeneration in whom there is rapidly progressing vision loss. The trial is being conducted at University College, London, in conjunction with Pfizer. Participants will receive the RPE cells, which have been made from human embryonic stem cells, embedded on a membrane which will be inserted into the eye. Participants will be monitored for complications including infection and tumour growth, as well as structural evidence of successful engraftment and changes to vision. The trial is not yet open but expects to enrol 10 subjects by December 2015.


    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Embryonic Stem Cells
  • Clinical Trial of Autologous Intravitreal Bone Marrow CD34+ Stem Cells for Retinopathy Location: US
    Overview: This pilot clinical trial is designed to evaluate the safety and effectiveness of transplanting bone marrow stem cells into the eyes patient’s with irreversible vision loss from various retinal degenerative conditions including macular degeneration, retinitis pigmentosa, diabetic retinopathy or retinal vein occlusion. The trial is being conducted by the University of California Davis. Participants will receive their own cells, isolated from their bone marrow, directly into the eye (intravitreal injection). Participants will be monitored for complications including infection and tumour growth, as well as structural evidence of successful engraftment and changes to vision. The trial expects to enrol 15 subjects by December 2013.
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With Advanced Dry Age Related Macular Degeneration Location: US
    Overview: This trial is designed to evaluate the safety and effectiveness of transplanting retinal pigment epithelial cells (RPE) in patients with dry Age Related Macular Degeneration. The trial is being conducted at Jules Stein Eye Institute, UCLA School of Medicine in California, Bascom Palmer Eye Institute in Florida, Mass Eye and Ear in Boston and the Wills Eye Institute-Mid Atlantic Retina in Philadelphia, in conjunction with Advanced Cell Technology. Participants will receive different doses of the RPE cells, which have been made from human embryonic stem cells. Participants will be monitored for complications including infection and tumour growth, as well as structural evidence of successful engraftment and changes to vision. The trial expects to enrol 16 subjects by July 2014.


    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Embryonic Stem Cells