Trials in Australia

There are many clinical trials underway in Australia to evalutate potential new treatments. The following are a list of trials using stem cells for various conditions. Visit the Australian New Zealand Clinical Trial Registry and the Australian Clinical Trials website to find out more about clinical trials that are happening here.

Trails tagged as Trials in Australia

  • Condition: Graft Versus Host Disease Mesenchymal Stromal Cells for Acute Graft Versus Host Disease
    Overview: This trial is investigating the possible beneficial effect of mesenchymal stem cell transplantation in acute graft versus host reaction following bone marrow transplantation or donor lymphocyte cell therapy. The study is being undertaken at the Royal Perth Hospital in Western Australia where patients with newly diagnosed, untreated grade 2-4, acute graft versus host disease will be randomly assigned to control and treatment arms of the study. Those in the control group will receive standard treatment (methylprednisolone intravenously). Those in the treatment group will receive standard treatment plus donated mesenchymal stem cells intravenously. Participants will be assessed for complications and any changes in clinical condition. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Osteoarthritis HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure
    Overview: This is an observational registry of patients who have their own fat stem cells as treatment for osteoarthritis. The long-term observational study is to assess the incidence of infection as well as the long term safety and effectiveness of injecting fat derived stem cells into the joints of patients with Grade 2, 3 or early Grade 4 osteoarthritis. The treatment is a proprietary procedure delivered in centres around Australia inconjunction with HiQ Cell- Regeneus Ltd. The cells used for the treatment are harvested from fatty tissue and injected without expansion into the affected joint. All participants undergoing the procedure will be interviewed and assessed using a combination of standard measures at regular intervals for 5 years. The first patients underwent this procedure in July 2012 and the study aims to observe 1000 patients. No completion date is provided.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Condition: Brain tumours Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours
    Overview: This trial aims to assess the safety and effectiveness of using blood stem cells that have been genetically modified to treat children with brain tumours. The clinical trial is being conducted by the Kids Cancer Project in Alexandria New South Wales in conjunction with the Australian Department of Innovation, Industry Science and Research. The trial hopes to recruit 15 children with either high grade primary Glioma or lower grade recurrent brain tumours such as Glioma, Ependymoma, Medulloblastoma or teratogenic tumours among others. Stem cells will be harvested from the participant's blood after they have received an injection of granulocyte colony stimulating factor (G-CSF) to release the stem cells from their bone marrow. The stem cells will be genetically modified in the laboratory to make them more resistant to chemotherapy drugs. The trial participants will receive an intravenous (IV) infusion of these expanded, modified stem cells, and then 21 days later be treated with standard chemotherapy for such tumours. Participants will be monitored for complications and the effectiveness will be assessed by conducting MRI scans of the brain. The trial commenced in July 2012.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Bone repair Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials
    Overview: This pilot study aims to demonstrate the safety and effectiveness of using the patient's own mesenchymal stem cells in cranial reconstruction. The trial being conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015 and expects to enrol 10 participants who require cranial reconstruction as a result of surgery or trauma. This trial proposes to use an implant that is customised to match the skull defect and is a sandwich of a scaffold embedded with mesenchymal stem cells that have been harvested from the patient and expanded in the laboratory. It is expected that the stem cells will multiply to occupy the scaffold with bone generating cells, which will eventually replace the entire scaffold with new bone. Participants will be assessed for complications. Bone formation will be monitored by CT scanning.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Leukaemia Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia
    Overview: This trial aims to evaluate stem cell transfusions from partially mismatched donors for patients with acute myeloid leukaemia (AML).The clinical trial is being conducted at St Vincent's Hospital in Sydney and proposes to enrol 12 patients with AML between November 2012 and January 2015. Participants will receive a nine-day induction chemotherapy treatment for AML. Concurrently the donor receives five days of G-CSF injections, starting on day four. On day 9, the stem cells will be harvested from the donor's peripheral blood via apheresis. The stem cells are divided into four aliquots, the first of which is injected into the patient on the same day. A bone marrow biopsy will be performed between four to five weeks after the stem cell infusion and if remission is confirmed, the patient will be commenced consolidation chemotherapy. If remission is not confirmed, the patient will receive another nine days of induction chemotherapy followed by an aliquot of stem cells and have a further bone marrow biopsy after four weeks. If the patient is seen to be in remission two further cycles of consolidation chemotherapy are given each followed by an aliquot of stem cells. Participants will be monitored for complications and assessed for changes in their clinical condition, including monitoring for evidence of graft versus host disease.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Osteoarthritis The Osteoarthritis Stem Cell Advanced Research Study
    Overview: This trial is investigating the use of stem cells from the patient's own fat in the treatment of osteoarthritis of the knee. This trial being jointly conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. Stem cells were isolated following liposuction and injected directly into patient's knee. Participants will be monitored for complications and assessed for changes in their clinical condition. The study commenced in February 2011 and has enrolled 40 subjects. The trial is still open but not recruiting any further subjects. Results are yet to be published.z
    Link to Clinical Registry
    Trial Design: Therapeutic intervention
    Status: Completed
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Condition: Rheumatoid Arthritis Long Term Follow-up of Patients with Severe Systemic Sclerosis and Rheumatoid Arthritis who have Undergone Haematopoietic Stem Cell Transplantation
    Overview: This observational study is a retrospective review of patients with severe systemic sclerosis and rheumatoid arthritis that have had a blood stem cell transplantation as a means of immunosuppression to achieve disease remission. The study is being conducted by the Haematology Department of St Vincent's Hospital in Sydney. Patients identified to have had haematopoietic stem cell transplantation in the previous 15 years for systemic sclerosis and rheumatoid arthritis will be invited to participate in this study. The participants will be required to fill out questionnaires documenting and quantifying the progress, current state of their illness and how it impacts their daily life. After reviewing this information, suitable patients will be invited to attend an interview where details of their medical history and prior procedure will be recorded. All this information will be used to record the primary outcome measure i.e. safety and effectiveness of Haematopoietic Stem Cell Transfer (HSCT). The patients will also be required to have a sample of blood drawn for stem cell markers to determine the degree of disease activity. The trial began in August 2008 with a view to recruiting 25 patients is still open and recruiting patients.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Osetoarthritis Adipose-Derived Stem Cells in Patients with Knee Osetoarthritis
    Overview: This trial aims to compare the effect of the patient's own fat stem cells in the treatment of osteoarthritis of the knee. The trial is being conducted by the Lakeside Medical Centre in Albert Park and the Australian Catholic University in Melbourne. The trial that has not started yet according to the registration information, but proposes to recruit 60 patients. Participants will be randomly assigned into two different categories. One group will receive an injection of hyaluronic acid derivative (Hylan GF). Another group will receive a suspension of cells derived from liposuction. The information provided on the ANZCTR indicates that the subjects will receive three injections but does not provide further details about the preparation of the cells. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Fatty Tissue Stem Cells
  • Condition: Peripheral Vascular Disease Stem Cells for Peripheral Vascular Disease
    Overview: This trial aims to compare the effect of the patient's own blood stem in treating patients with severe peripheral arterial disease. The trial is being conducted at the Alfred Hospital in Melbourne and proposes to recruit 20 subjects. The subjects will be randomly assigned to two groups. They will either receive a single injection of CD 34+ stem cells via the limb artery (experimental group) or a placebo injection (control group). Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Not yet started
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Tendon repair A Phase 1 Study to Evaluate the Potential Role of Mesenchymal Stem Cells in the Treatment of Chronic Refractory Tendinopathy
    Overview: This trial is investigating the effects of umbilical cord stem cells in treating tendon repair. The study has being conducted by the Mater Medical Research Institute and Mater Health in Brisbane, Queensland and proposes to recruit nine patients with clinically and ultrasound diagnosed Achilles tendonopathy. Participants will be divided into one of three groups each receiving different doses of stem cells injected directly into damaged tendon. The trial partially complete but is currently on hold. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Condition: Multiple Myeloma Quality of Life Assessment and Overall Survival in Patients with Mulitple Myeloma after Tandem Autologous Stem Cell Transplantation
    Overview: This trial is investigation the use of the patient's own stem cells in the treatment of patients with multiple myeloma. The trial is being conducted by the Haematology Department of Launceston General Hospital in Tasmania. This ongoing trial commenced in July 2007 and expects to recruit 40 patients. Participants will receive G-CSF injection five days prior to harvesting peripheral blood stem cells via apheresis. The peripheral blood stem cells will be divided into two samples. The first sample will be administered to the patient once they have received a dose of ablative chemotherapy. The second sample will be administered three months later, after another dose of ablative chemotherapy. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Blood Stem Cells
  • Condition: Leukaemia A Pilot Study of the Role of CD133+ as a Cell Marker for Human Haematopoietic Stem Cells
    Overview: This is an observational study being conducted to determine if a specific category of cells (CD 133+) in a standard blood stem cell transplant affects the degree of successful engraftment. The study is being undertaken by the Pathology Department of the Launceston General Hospital in conjunction with the University of Tasmania. This ongoing study commenced recruitment in March 2009 and expects to enrol 40 participants.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Leukaemia A phase 1 Multicentre Open Label Dose-Escalation Study of Unrelated, Major Histocompatibility-unmatched Mesenchymal Stem Cells for the Treatment of Steroid Refractory Acute Graft Versus Host Disease in Recipients of Allogeneic Heamatopoietic Stem Cell Transplants
    Overview: This trial aims to evaluate the effect of the transplantation of unmatched bone marrow derived mesenchymal stem cells in the treatment of acute graft versus host disease occurring as a result of a previous donated haematopoietic stem cell transplant. The study is being conducted at the Mater Medical Research Institute and Mater Health in Brisbane and is expected to enrol nine subjects. All participants will receive donated, unmatched, bone marrow derived mesenchymal stem cells and one of three different, escalating doses. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Cornea damage Epithelial Cell Transfer for Severe Corneal Disease
    Overview: This trial aims to evaluate a new contact lens system to culture and transfer limbal stem cells to the corneal surface in patients with limbal stem cell deficiency. The trial is being conducted by the the School of Medical Sciences at the University of New South Wales. Limbal stem cells will be harvested from the patient unaffected eye and will then be cultured on specially designed contact lens, before being transferred to the patient's cornea. Participants will be monitored for complications and assessed for changes in their clinical condition, including examination of ocular health and corneal epithelium integrity. The trial started in May 2007 and expects to recruit 30 patients with limbal stem cell deficiency.z
    Link to Clinical Registry
    Trial Design: Safety and Efficacy Study
    Status: Open - Recruiting
    Stem Cell: Stem Cells (unspecified)
  • Condition: Leukaemia Evaluation of Engraftment Kinetics Following Double Unit Umbilical Cord Blood Transplantation in Patients with Life Threatening Haematological Malignancy
    Overview: This trial is designed to investigate the use of a double unit umbilical cord blood infusion in patients with life threatening haematological malignancy but no suitable donor available. The study is being jointly conducted by the Australasian Leukaemia and Lymphoma Group and Amgen Australia. The trial aims to assess whether two units of donated cord blood would improve the engraftment rates as this remains low when only one unit is used. All participants will be monitored for complications and assessed for changes in their clinical condition. According to the information posted on the ANZCTR registry, the trial has not yet commenced.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Umbilical Cord Stem Cells
  • Condition: Leukaemia Phase II Study of Myeloablative Allogeneic Transplantation Using G-CSF Mobilised Peripheral Blood Stem Cells
    Overview: This trial is designed to evaluate the use of stem cells from a matched sibling in reducing the incidence of graft versus host disease (GVHD) in the treatment of haematological malignancy.The trial is being conducted by the Royal Brisbane and Women's Hospital in conjunction with the Queensland Institute of Medical Research. The trial started in June 2004 and proposes to enrol 47 patients with a haematological malignancy that requires chemotherapy and bone marrow transplant. Participants require a sibling with an identical HLA match as a donor for this trial. Donors will receive an injection of pegylated GCSF to release bone marrow stem cells into the circulation. The stem cells will be isolated from the donor's blood and provided to the trial participant once they have received their chemotherapy The patient will then be monitored for complications including for acute GVHD.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Multiple Sclerosis and Chron's Disease A Single Centre Phase II Study Of Haematopoietic Stem Cell Transplantation for Severe Auto-Immune Diseases
    Overview: This trial is evaluating the use of combining immunosuppression and the patient's bone marrow stem cells in patients with serious diseases of the immune system which have not responded to conventional treatments. The trial is being conducted at St Vincent's Hospital in Sydney and began recruiting patients in March 2011 with plans to recruit 30 subjects by December 2015. The conditions being investigated in the trial include Scleroderma, Multiple Sclerosis, Systemic Lupus Erythematosus (SLE), vasculitis, Crohn's disease and Behcet's disease. Participants will be given Granulocyte Colony Stimulating Factor (G-CSF) to stimulate the bone marrow into releasing stem cells, which will then be harvested from the blood of each participant. The patients will then undergo a course of intensive chemotherapy and/or immunotherapy depending on the individual condition after which they will receive an infusion of their own stem cells. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells
  • Condition: Leukaemia and Lymphoma Haploidentical Donor Stem Cell Transplantation for Haematological Malignancies
    Overview: This trial aims to investigate the use of blood stem cells from related donors for the treatment of haematological malignancies such as leukaemia and lymphoma. The trial is being conducted at St Vincent's Hospital in Sydney plans to recruit five patients between May 2009 and February 2014. Participants will receive stem cells from a related donor (haploidentical identical) blood stem cells. Donors will be injected with GCSF following which they will have stem cells harvested from their bone marrow as well as from their peripheral blood (GCSF primed bone marrow harvest + augmentation with peripheral blood stem cells). Patients will initially undergo chemotherapy following which they will be injected with donated stem cells. The patients will also be given the standard GVHD prevention immunosuppression regime. Participants will be monitored for complications and assessed for changes in their clinical condition.z
    Link to Clinical Registry
    Trial Design: Observational Study
    Status: Open - Recruiting
    Stem Cell: Adult Bone Marrow Stem Cells