Dr Alberto Rosello-Diez

 - Associate Investigator

Research focus: Local and systemic mechanisms that regulate bone growth in limbs and communication between bone and the rest of the body

Dr Alberto Roselló-Díez’s main interest is how cells collect and process information to make decisions, and how the combination of these individual decisions leads to collective outcomes. He studies vertebrate limb development to address these questions.

Alberto received his PhD in 2011 for his work in the group of Dr. Miguel Torres (Madrid, Spain). Using chicken and mouse models, they discovered that instructions from outside the limb interact with an intrinsic cell timer to lay down the shoulder-to-digit axis. In 2012 he joined the Joyner laboratory at Memorial Sloan Kettering Cancer Center (New York) as a postdoctoral fellow. Alberto conceived and developed mouse genetic models of unilateral perturbations of limb growth, to study the repair of developmental defects. These studies led to the discovery that not only the injured organ, but also other organs, participate in the response to the perturbation, giving rise to a new collective view of organ repair, where multiple tissues interact.

In May 2018, Alberto joined the Australian Regenerative Medicine Institute (Monash University) as a Group Leader. His laboratory studies the organ-repair responses activated by developmental perturbations, addressing two main topics:

1- Local mechanisms that cope with perturbations in growing bones.
2- Inter-organ communication mechanisms that maintain body proportions when individual organs are damaged during development.

In the long term, the goal of the lab is to learn how to re-activate or boost the cells and responses uncovered by these studies, including rare stem cell populations. This will lead to new regenerative therapies for disorders such as dwarfism or intra-uterine growth restriction.