Dr John Haynes

 - Chief Investigator

Research focus: Stem cell-based models of neuropsychiatric and neurodegenerative diseases - embryonic stem cell reporter lines and enrichment of neural phenotypes

Dr John Haynes is an academic scientist based within the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (Parkville campus). He is a classically trained pharmacologist with expertise in cellular signalling and the regulation of cell survival and function. Much of his past work has utilised genomic and proteomic approaches, as well as ion imaging, to reveal the roles of protein kinases and ion channels in regulating cell function and survival.  His current research activities are conducted within the Drug Discovery Biology research theme at the Monash Institute of Pharmaceutical Sciences (MIPS) where he co-leads the Stem Cell Biology Group. The Stem Cell Biology Group works around the basic idea that embryonic stem cells provide an excellent platform for disease modelling, drug discovery and investigations of human cell physiology. To facilitate this current work we have created a number of fluorescent protein/enzyme-tagged reporter cell lines suitable for simple screening and functional assays. The focus of these assays is the identification of new therapeutic targets that minimise neuron death.  More recently we have begun development of more sophisticated systems employing forebrain and midbrain neuron networks, complete with astrocytes and microglia, to directly explore the impact of inflammation upon neuron function.