Profiles

Dr Mikael Martino

 - Chief Investigator

Research focus:  Research in immunology, stem cells, and bioengineering, to understand molecular and cellular mechanisms governing tissue repair and regeneration and to engineer novel regenerative strategies


Mikael Martino’s group combines research in immunology, stem cells, and bioengineering, in order to understand the molecular and cellular mechanisms governing tissue repair and regeneration. Using the findings from the lab, the group aims at engineering novel regenerative strategies.
To design successful regenerative therapies and make regenerative medicine a more widespread reality, we need to understand how our body is able to create an environment suitable for regeneration. For instance, tissue injury and the healing process are usually accompanied with the activation of our immune system. The type of immune response, its duration, and the cells involved can considerably change the outcome of the healing process from incomplete restoration (causing scarring/ fibrosis and loss of function) to complete recovery (regeneration).

One of the main goals of the group is to reveal the key mechanisms by which the immune system leads to tissue repair or regeneration. Our research tools include genetically modified and chimeric mice as well as injury models in tissues such as bone, skin and muscle. Ultimately, the group seeks to engineer efficient regenerative strategies that integrate control of the immune system using various bioengineering approaches (such as biomaterials, protein engineering or immunoengineering).