Associate Professor Mirella Dottori

 - Chief Investigator

Research focus: Using neural stem cells to generate neuronal cell types - applications in Parkinson's disease, Friedreich's ataxia, Hirschsprung's disease, peripheral neuropathies and hearing loss

Dr Mirella Dottori is currently Group Leader of the Stem Cell Laboratory within the Centre for Neuroscience at University of Melbourne. Her PhD (Walter and Eliza Hall Institute) and postdoctoral studies (Salk Institute, USA) were on understanding early neural specification and patterning within the nervous system. Dr Dottori returned to Australia as a NHMRC Howard Florey Fellow where she joined Professor Martin Pera’s group at Monash University working on human embryonic stem cells. In 2007, together with Dr Pebay, Dr Dottori established Stem Cell Laboratory at the University of Melbourne.

Dr Dottori and her research team have developed highly efficient systems for deriving neuronal lineages from human pluripotent stem cells for their use in cell replacement therapies as well as establishing neural cellular models of development and disease.  The major neurodegenerative diseases her research is focused on includeFriedreich Ataxia, Parkinson's Disease and Multiple Sclerosis. Dr Dottori is able to bring to Stem Cell Australia her expertise in differentiation of human pluripotent stem cells to specific neuronal progenitor populations, including their genetic manipulation. Her collaborations with Dr Lachlan Thompson, Dr Clare Parish and Dr Bryony Nayagam have helped build a multidisciplinary research platform that examines the in vivo and in vitro functional potential of stem cells and their neural derivatives within the nervous system.