Professor Andrew Elefanty

 - Partner Investigator

Professor Andrew Elefanty will contribute his expertise in the directed differentiation of human pluripotent stem cells to the Stem Cells Australia initiative. His input into the program will be to utilise his established expertise in hESC biology, culture, expansion, differentiation and genetic manipulation, as well as extensive experience in hematology and developmental biology.

Professor Elefanty works in close collaboration with the laboratories of Professor Ed Stanley and Dr David Elliott at the Murdoch Childrens Research Institute (MCRI). Their core interest lies in the regulation of human pluripotent stem cell differentiation to mesendodermal precursors (corresponding to the primitive streak in the mammalian embryo) and then to hemogenic endothelial cells and blood. Although most of our work has been with hESCs, we have begun to culture and differentiate hiPSCs, demonstrating that our protocols developed for hESCs are also applicable to hiPSCs.