Michal Mor

Neuroscience A/Prof Mirella Dottori
PhD Student at the Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne
Recipient of scholarship
Type 1 diabetes mellitus (T1D) is an early onset childhood disease with increasing incidence worldwide. Children and adolescents with T1D are more likely to suffer from neurocognitive deficits.

My aim is to better understand the direct effects of hyperglycemia on neuronal structure and function in the brain. I use cortical neurospheres created from hESC and iPSCs, as an in vitro model of cellular self-organisation of the forebrain cerebral cortex in the developing brain, allowing practicable manipulation of the external environment, in the absence of other complicating factors.  I first established culture conditions for hESC neural induction to mimic the physiological levels of glucose and insulin within the human brain. This was followed by exposing the hESC\ iPSC -derived cortical neurospheres to a T1D-like micro-environment and investigating how altered glucose\insulin levels may impact neurogenesis and neuronal differentiation.  

Contact student by mmor@student.unimelb.edu.au