What's On

VIC Stem Cell Network - December 2015

04:00 PM - Tuesday 01 December, 2015
Join us to hear Dr Samir Taoudi from WEHI discuss haematopoiesis during embryonic development.

Time:  4pm – 5pm

Date:  Tuesday, 1st December, 2015

Venue:  Level 5, Seminar Rooms, MBC, Parkville



ABSTRACT: Haematopoietic development in the embryo occurs in a sequential process, during which primitive erythropoiesis and progenitor formation occurs in the yolk sac. Once this first wave of haematopoiesis is established HSCs are then formed; this is a complex multi-site process involving the AGM region, yolk sac and placenta. During foetal life the majority of HSCs reside within the liver, where HSCs continue to expand and initiate definitive haematopoiesis (a sustained haematopoietic system driven by a self-renewing HSC). The embryo provides an invaluable resource for tackling the problems central to haematopoiesis research, particularly the complex problem of how concomitant HSC self-renewal and hematopoietic differentiation can be achieved. I will be discussing how our laboratory is teasing apart these processes, with particular focus on identifying when specification of early haematopoietic lineages is first detectable. 

BIO: Samir Taoudi performed his PhD studies at the Institute for Stem Cell Research, University of Edinburgh, under the supervision of Professor Alexander Medvinsky. During this time Samir investigated the early lineage ancestry of the haematopoietic stem cell lineage within the mid-gestation embryo. In 2008 Samir took a post-doctoral position with Professor Douglas Hilton at The Walter and Eliza Institute, where he studied the role of the ETS transcription factor ERG during establishment of the embryonic haematopoietic system. In 2011 Samir accepted a faculty position at WEHI, his lab continues to investigate the control of blood cell formation in the prenatal mouse organism.