Join us to hear Professor Justin St John from Monash University discuss control of mitochondrial DNA replication during pluripotency and differentiation.
We would like to thank Lonza, Peprotech and BioGems for providing the catering for this event.
The control of mitochondrial DNA replication during pluripotency and differentiation
4:00PM on Tuesday 5 May 2015 (Refreshments to follow)
Level 5 Seminar Room, Melbourne Brain Centre, The University of Melbourne, Parkville
Professor Jus St. John was awarded his PhD from the University of Birmingham in 1999. Whilst in the UK, he was funded by the Medical Research Council and was appointed Professor of Reproductive Biology at the University of Warwick (2007). He is now the Head of the Centre for Genetic Diseases at MIMR-PHI Institute of Medical Research, Melbourne, Australia. His work focuses on how mitochondrial DNA is transmitted and replicated as it passes from the oocyte into the embryo and onto the offspring. He has recently demonstrated how mitochondrial DNA copy number is regulated in a cell-specific manner by DNA methylation of the nuclear-encoded mitochondrial DNA-specific polymerase; and how mtDNA haplotypes influence chromosomal gene expression patterns. He has also mapped mitochondrial DNA variants in tumour cells and shown that the presence of mtDNA is an important regulator of tumorigenesis. The outcomes of his work have important implications for the use of certain assisted reproductive technologies and for developing combination therapies for the treatment of cancer. He has published in The Lancet, Nature Chemical Biology, Nature Cell Biology, Nucleic Acids Research, Cell Death and Differentiation, Stem Cells, Journal of Cell Science,
In 2013, he received the Society for Reproductive Biology’s Award for Excellence in Reproductive Biology Research.