Join us on Tuesday 3 December to hear The University of Melbourne's Dr Lincon Stamp discuss neural stem cell therapy for gut motility disorders. Refreshments to follow.
VENUE: Level 5 Seminar Room, Melbourne Brain Centre, The University of Melbourne
ABSTRACT: The enteric nervous system is derived from the neural crest and plays an important role in the control of motility, blood flow and secretion along the gastrointestinal tract. Aberrant proliferation, migration and/or differentiation of the neural crest can result in a failure to appropriately colonise the entire length of the gastrointestinal tract; as occurs in Hirschsprung disease. Current treatment, which involves surgical resection of the defective, aganglionic bowel, is life saving, but a large proportion of patients have ongoing chronic complications. Stem cell therapy offers a potential alternative treatment to generate new enteric neurons in the bowel of patients with Hirschsprung disease and other more common enteric neuropathies such as diabetic gastro paresis. We examined whether transplanted neural stem/progenitor cells can migrate and generate functional neurons in the post-natal bowel in vivo. I will discuss our different strategies to generate new enteric neurons in the bowel of postnatal wildtype and HSCR disease model mice.
BIO: Dr Stamp completed his PhD at Monash University in the laboratory of Prof Martin Pera, where he worked on characterisation of a novel cell surface marker and its role in the isolation of endodermal progenitors from differentiating human embryonic stem cells. Lincon worked with Dr Don Newgreen at the Murdoch Childrens Research Institute before moving to the laboratory of Prof Heather Young in 2012 at The University of Melbourne, Department of Anatomy and Neuroscience, to work on developing a stem cell therapy to treat diseases of the enteric nervous system. Specifically, his work has focused on using stem cells from a variety of sources to repopulate the aganglionic region of bowel in Hirschsprung disease, utilising mouse models of the disease.