Join us on Tuesday 2 July 2013 to hear A/Prof Ann Turnley from University of Melbourne discuss what it will take to make endogeneous neural stem cells repair the nervous system.
Time: 4pm – 5pm (refreshments served following seminar)
Venue: Level 5 Seminar room, Melbourne Brain Centre, The University of Melbourne
ABSTRACT: What will it take to make endogenous adult neural stem cells repair the adult nervous system?
It has been known for two decades that the adult brain contains niches of neural stem cells that normally produce new neurons in the subventricular zone of the lateral ventricles and the dentate gyrus of the hippocampus. Since their discovery a lot of effort has been spent, with limited success, to enhance the ability of these neural stem cells to promote repair after injury or disease of the nervous system. Not only does production of neural precursor cells need to be increased to generate sufficient numbers for repair, the precursor cells need to migrate to the site of damage, differentiate into the right sort of neuron or glial cell and, perhaps most importantly, survive and integrate appropriately into the local neural circuitry. Most newborn neurons that are produced die within 1 month of their generation and so do not contribute to regeneration. Factors that regulate each of these steps – proliferation, migration and differentiation will be discussed, with a focus on our current work aiming to promote survival and integration of newborn neurons following traumatic brain injury to improve functional outcome and neural repair.
BIO: Ann Turnley obtained a BSc(Hons) from the University of Melbourne and a PhD, based at the Walter and Eliza Hall Institute of Medical Research, where she combined interests in immunology and neuroscience to examine a transgenic model of dysmyelination. She then continued her interest in regulation of myelination as a Lucille P. Markey Postdoctoral Fellow at the Brookdale Center for Molecular Biology, The Mount Sinai School of Medicine, New York, U.S.A. She then returned as an ARC Postdoctoral Fellow and then Sir Colin and Lady MacKenzie Postdoctoral Fellow in the Development and Neurobiology Group at the WEHI, where she developed an interest in neural stem cells and regulation of neural regeneration. In 2001 she moved to the Centre for Neuroscience at the University of Melbourne, where she set up the Neural Regeneration Laboratory, to investigate processes that inhibit regeneration and may be targeted to promote neural repair, using a range of molecular, cellular and animal models. Her lab has a particular focus on regulation of neurite outgrowth/axonal regeneration and harnessing of endogenous adult neural stem cells to repair the CNS after damage.