Join us for the first seminar of the 2015 series to hear Monash University's Associate Professor Helen Abud discuss stem cell maintenance and cell lineage allocation in the intestinal epithelium.
Title: Snai1 regulates stem cell maintenance and cell lineage allocation in the intestinal epithelium
Guest Speaker: Associate Professor Helen Abud, Head of the Epithelial Regeneration Laboratory, Monash University
Time: 4:00PM on Tuesday 3 February, 2015 (Refreshments to follow)
Venue: Level 5 Seminar Room, Melbourne Brain Centre, Parkville Campus
BIO: Helen Abud is a Senior Lecturer in Developmental Biology and Head of the Epithelial Regeneration Laboratory in the Department of Anatomy and Developmental Biology within the School of Biomedical Sciences at Monash University. Following her undergraduate degree at Melbourne University, she initially trained at the Walter and Eliza Hall Institute before undertaking her doctorate at Oxford University in cell and developmental biology. This was followed by postdoctoral training in the Department of Anatomy (Oxford), Peter MacCallum Cancer Centre (Melbourne) and the Ludwig Institute for Cancer Research (Melbourne). A/Prof Abud's current research is centred on understanding the molecular mechanisms and environmental influences that regulate stem cells within tissues. A/Prof Abud has a particular interest in molecules that promote intestinal epithelial development and regeneration following damage and how these factors may be altered in degenerative diseases and colon cancer.
ABSTRACT: The Snail family of transcriptional regulators mediate epithelial to mesenchymal transitions and cell motility during both embryonic development and cancer metastasis. Snail proteins have also been implicated in regulating stem cell populations in several organs. We are investigating the role of Snai1 in the mouse intestinal epithelium that is continuously renewed via a population of multipotent stem cells that reside in the base of crypts. Our studies have revealed that Snai1 is localised in crypt base columnar cells and is required for survival and function of intestinal stem cells. Comparison of phenotypes where Snai1 is either conditionally deleted or ectopically expressed in the mouse intestinal epithelium also demonstrates a key role for Snai1 in lineage specific differentiation of mature cell types.